Single-Cell Transcriptomic Analysis Reveals ISG15 as a Key Regulator of Macrophage-Mediated Inflammation Driving Primary Sjögren's Syndrome Progression
This integrated transcriptomic analysis highlights key monocyte-macrophage trajectories and identifies four robust immune-metabolism biomarker candidates for pSS diagnosis. Functional validation of ISG15 suggests it plays a pivotal role in driving macrophage-mediated inflammatory responses in pSS.
Authors
- Yalu Fu
- Kunting Chen
- Jun Dong
- You‐Chen Chao (ORCID: https://orcid.org/0000-0002-8831-2265)
Institutions
- Xinjiang Medical University (CN)
- Fifth Affiliated Hospital of Xinjiang Medical University (CN)
- Wuhan No.1 Hospital (CN)
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- Critical Reviews in Immunology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1615/critrevimmunol.2025060877
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00