Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis
Here, we demonstrate that both PET tracers detected Mtb infection. The inflammatory response tracked by [<sup>18</sup>F]FDG progressively increased in line with the developing TB pathology, while [<sup>18</sup>F]DPA714 showed a transient signal in lungs and lung-draining hilar lymph nodes. This study underpins the potential value of different tracers to investigate cellular and molecular host response cascades in experimental medicine settings, in this case, into a (transient) local involvement of myeloid immune cell activation versus inflammation-associated glucose consumption in pulmonary TB.
Authors
- Albert D. Windhorst (ORCID: https://orcid.org/0000-0002-1250-7656)
- Erik Nutma (ORCID: https://orcid.org/0000-0002-7332-1636)
- Claudia C. Sombroek (ORCID: https://orcid.org/0000-0002-7728-6030)
- Marieke A. Stammes (ORCID: https://orcid.org/0000-0003-4261-6535)
- Jaco Bakker (ORCID: https://orcid.org/0000-0001-6670-1887)
- Lisette Meijer
- Ivanela Kondova
- Jan A. M. Langermans (ORCID: https://orcid.org/0000-0002-4806-4412)
- Michel Vierboom (ORCID: https://orcid.org/0000-0002-1865-7532)
- Frank A. W. Verreck (ORCID: https://orcid.org/0000-0002-4441-5000)
- Sam Hofman (ORCID: https://orcid.org/0000-0002-0174-1375)
- Richard A. W. Vervenne (ORCID: https://orcid.org/0000-0001-6167-1674)
Institutions
- Utrecht University (NL)
- Biomedical Primate Research Centre (NL)
- Amsterdam Neuroscience (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1007/s11307-025-02057-6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases