Acupuncture improves depression-like behaviors in rats through gut microbiota and TLR4/MyD88/NF-κB pathway modulation
Acupuncture alleviates CUMS-induced depressive-like behaviors. The benefits are associated with gut microbiota remodeling, inhibition of TLR4/MyD88/NF-κB signaling, and stabilization of HPA-axis function, supporting an immune-microbiota-neuroendocrine mechanism.
Authors
- Simin Yan
- Tiansheng Zhang (ORCID: https://orcid.org/0000-0002-8977-6117)
- Shuqiong Huang (ORCID: https://orcid.org/0000-0002-4276-539X)
- Muhammad Shahzad Aslam (ORCID: https://orcid.org/0000-0003-2728-6726)
- Yanyan Lin (ORCID: https://orcid.org/0009-0004-3472-6990)
- Hui Fang (ORCID: https://orcid.org/0000-0001-9365-7420)
- Yanbei Zhan (ORCID: https://orcid.org/0000-0003-1440-2855)
- Xianjun Meng (ORCID: https://orcid.org/0000-0003-4609-9248)
- Jianguo Li (ORCID: https://orcid.org/0000-0002-2251-8308)
- Peng Li (ORCID: https://orcid.org/0000-0003-2030-1807)
- Liu Ning (ORCID: https://orcid.org/0000-0002-2144-9478)
- Li Meng (ORCID: https://orcid.org/0000-0002-0224-9833)
- Jingxuan Li (ORCID: https://orcid.org/0000-0003-2504-837X)
- Junliang Shen
- Jingyu Zeng
- Zhuoran You
Institutions
- Hebei University of Engineering (CN)
- Union Hospital (HK)
- Xiamen University (CN)
- Xiamen University Malaysia (MY)
- Affiliated Hospital of Hebei University (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111590
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73