Sex and age-related differences in humoral and cellular responses to the recombinant zoster vaccine in people living with HIV
RZV vaccination effectively induces both humoral and T-cell immunity in PLWH. However, host factors, such as sex and age, critically modulate immunogenicity. Females < 60 years showed a superior humoral response and the strongest association between immune compartments, highlighting important variability in vaccine responsiveness.
Authors
- Leire Pérez‐Latorre (ORCID: https://orcid.org/0000-0001-9919-3778)
- Salvador Resino (ORCID: https://orcid.org/0000-0001-8783-0450)
- Chiara Fanciulli (ORCID: https://orcid.org/0000-0003-2175-9027)
- Teresa Aldámiz‐Echevarría (ORCID: https://orcid.org/0000-0002-4374-6940)
- Isidoro Martínez (ORCID: https://orcid.org/0000-0002-9949-9264)
- Francisco Tejerina (ORCID: https://orcid.org/0000-0002-4136-3575)
- Isabel Gutiérrez (ORCID: https://orcid.org/0000-0001-8420-5086)
- Cristina Díez (ORCID: https://orcid.org/0000-0002-3508-9979)
- Daniel Sepúlveda‐Crespo (ORCID: https://orcid.org/0000-0002-8053-6045)
- Carlos Pita-Martínez
- Marta Quero‐Delgado (ORCID: https://orcid.org/0009-0003-8097-0137)
- Juan Carlos López
- Aurora Gómez-Tórtola
- Ana Marchan
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Centro Nacional de Microbiologia (ES)
- Centro de Investigación Biomédica en Red (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.biopha.2025.118663
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00