P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A/Nrp1 Via TLR-4
Our data identify the Sema3A-Nrp1 axis as a P-LPS-sensitive regulator of bone homeostasis, offering therapeutic potential to reverse infection-induced osteolysis through dual modulation of osteoclast and osteoblast activities. Sema3A attenuated PLPS- driven bone loss via concurrent osteoclast inhibition and osteoblast stimulation CLINICAL RELEVANCE: Our work identifies the above dual-targeting mechanism as a foundation for novel therapies against infection-related oral osteolysis.
Authors
- Xiaoli Hu (ORCID: https://orcid.org/0000-0002-0462-7500)
- Quan Xing (ORCID: https://orcid.org/0000-0001-6367-5863)
- Sang Phan
- Jingyi Feng (ORCID: https://orcid.org/0000-0001-5064-7484)
- Dongjie Fu
Institutions
- Sun Yat-sen University (CN)
- University of Cambodia (KH)
- Wuhan University (CN)
- Stomatology Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.identj.2025.103941
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81