S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation
These findings indicate that downregulation of S100A10 exacerbates PE-induced cardiomyocyte hypertrophy and uncover a novel function of S100A10 in modulating mitochondrial respiratory chain protein levels, potentially through the mTOR/4E-BP pathway. This may provide a theoretical basis for future therapeutic strategies.
Authors
- Feixue Xu
- Jiahao Li (ORCID: https://orcid.org/0000-0002-7002-998X)
- Dan Li (ORCID: https://orcid.org/0000-0002-1264-5952)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4935-4005)
- Man Xu (ORCID: https://orcid.org/0000-0002-2592-5937)
- Wanyi Li (ORCID: https://orcid.org/0000-0001-7008-5909)
- Yajie Chen (ORCID: https://orcid.org/0000-0001-6567-0396)
- Yinshan Lu
- Yingying Guo
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fgene.2025.1610008
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Young Scientists Fund