The influence of body mass index on Tumor Treating Fields therapy in patients with metastatic non-small cell lung cancer: A post-hoc and simulation analysis from the phase III LUNAR study
In this post-hoc analysis, we found no difference in OS benefit of TTFields therapy between patients with BMI < 25 kg/m<sup>2</sup> versus ≥ 25 kg/m<sup>2</sup>. Simulation data demonstrated the feasibility of delivering TTFields at therapeutic intensities to the lungs regardless of BMI.
Authors
- Lukas Weiß (ORCID: https://orcid.org/0000-0002-2174-5613)
- Ticiana A.B. Leal (ORCID: https://orcid.org/0000-0002-3735-9063)
- Wallace Akerley (ORCID: https://orcid.org/0000-0002-3090-4778)
- Rupesh Kotecha (ORCID: https://orcid.org/0000-0001-6927-0402)
- David E. Gerber (ORCID: https://orcid.org/0000-0002-7812-6741)
- Ariel Naveh
- Christian Diego Rolfo (ORCID: https://orcid.org/0000-0002-7860-8417)
- Corey J. Langer (ORCID: https://orcid.org/0000-0002-8483-6811)
- Jeffrey P. Ward (ORCID: https://orcid.org/0000-0002-9707-895X)
- Nadav Shapira
Institutions
- Baptist Hospital of Miami (US)
- Emory University (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- Paracelsus Medical University (AT)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Huntsman Cancer Institute (US)
- Southwestern Medical Center (US)
- Baptist Health South Florida (US)
- Southwestern Medical Center (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Lung Cancer
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.lungcan.2025.108802
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00