Jiao-tai-wan and its component coptisine attenuate PCOS by regulating mitochondrial cholesterol import through suppression of SIRT1 ubiquitination
JTW and its component, coptisine, modulate mitochondrial dynamics by inhibiting SIRT1 ubiquitination to restrict StAR-mediated mitochondrial cholesterol import, thereby normalizing abnormal ovarian steroidogenesis and attenuating PCOS. Furthermore, this study provides novel evidence that coptisine functions as a natural stabilizer of SIRT1 protein.
Authors
- Yueheng Tang
- Hongzhan Wang
- Xinyue Jiang (ORCID: https://orcid.org/0000-0001-7205-6992)
- Hui Dong (ORCID: https://orcid.org/0000-0003-4771-0846)
- Hao Su (ORCID: https://orcid.org/0000-0002-7957-5442)
- Ping Ma (ORCID: https://orcid.org/0000-0002-2446-3849)
- Zhi Wang (ORCID: https://orcid.org/0000-0002-5276-1413)
- Xiaohu Xu (ORCID: https://orcid.org/0000-0002-0970-9337)
- Yang Gao (ORCID: https://orcid.org/0000-0002-7910-3787)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.phymed.2025.157446
- Citations
- 2
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.61