Fufang Danshen Pill improves mitochondrial homeostasis by regulating the S100a9/TLR4 axis to alleviate myocardial ischemia-reperfusion injury
This study demonstrates that macrophage-derived S100a9 mediates mitochondrial damage in cardiomyocytes during I/R injury. FDP effectively maintains mitochondrial functional homeostasis in cardiomyocytes by targeting and inhibiting macrophage S100a9 expression. These findings provide a important scientific basis for developing intervention strategies targeting the S100a9/TLR4 axis.
Authors
- Song Zhu (ORCID: https://orcid.org/0000-0003-3409-1740)
- Wenyong Lin
- Wenhao Sun
- Ruixia Lu (ORCID: https://orcid.org/0000-0002-3294-4298)
- Zhenchi Sang
- Dan Wang (ORCID: https://orcid.org/0000-0002-3814-7556)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0001-9906-5522)
- Qipeng Jin
- Dongyuan Wang (ORCID: https://orcid.org/0009-0005-6904-6247)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.phymed.2025.157433
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35