Loss of NcBPK1 impairs bradyzoite differentiation and enhances virulence in Neospora caninum
These findings indicate that NcBPK1 is crucial for regulating the balance between acute replication and chronic persistence. Its absence promotes rapid tachyzoite proliferation and worsens disease outcomes. This study sheds light on the molecular mechanisms underlying N. caninum virulence. Further research is needed to elucidate the signaling pathways and protein interactions involving NcBPK1.
Authors
- Ghalia Boubaker (ORCID: https://orcid.org/0000-0003-0475-7548)
- Andrew Frederick Hemphill (ORCID: https://orcid.org/0000-0002-0622-2128)
- Rafael Amieva (ORCID: https://orcid.org/0000-0002-9557-823X)
- Esther Collantes-Fernández (ORCID: https://orcid.org/0000-0002-1601-6889)
- Iván Pastor‐Fernández (ORCID: https://orcid.org/0000-0001-8454-5654)
- Pilar Horcajo (ORCID: https://orcid.org/0000-0001-9758-7765)
- Laura Rico-San Román (ORCID: https://orcid.org/0000-0002-5414-0944)
- Luis Miguel Ortega‐Mora (ORCID: https://orcid.org/0000-0002-4986-6783)
Institutions
- University of Bern (CH)
- Universidad Complutense de Madrid (ES)
- Department of Animal Health (VN)
- Institute of Parasitology (CZ)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13071-025-07076-4
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00