Aging as an active player in Alzheimer’s disease classification: Insights from feature selection in BrainAge models
Aging significantly affects BrainAge-based classification of Alzheimer's disease. Feature selection plays a critical role in mitigating this effect, as the outputs of models trained to predict age, the deltas, may fail in Alzheimer´s disease classification. These findings underscore the need for task-specific feature selection and model design to ensure that BrainAge models are appropriately applied in neurodegenerative disease research.
Authors
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Jorge García Condado (ORCID: https://orcid.org/0000-0002-9463-1924)
- Jesús M. Cortés (ORCID: https://orcid.org/0000-0002-9059-8194)
- Asier Erramuzpe (ORCID: https://orcid.org/0000-0002-9402-2184)
- Iñigo Tellaetxe Elorriaga (ORCID: https://orcid.org/0009-0001-1832-5183)
- Maria Carrigan
- Ines Verdugo Recuero
- Colin Birkhenbil
Institutions
- Ikerbasque (ES)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- BioCruces Health research Institute (ES)
- Amsterdam Neuroscience (NL)
- Bioef - Fundación Vasca de Innovación e Investigación Sanitarias (ES)
- Universidad Carlos III de Madrid (ES)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121548
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Ikerbasque, Basque Foundation for Science
- Ministerio de Ciencia e Innovación
- Servier
- H. Lundbeck A/S
- IXICO
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research