An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease

We have defined differences in the epithelial stem and progenitor compartment of patients with Crohn's disease that suggest aberrant stem cell differentiation and inflammatory gene expression arise and persist during disease.

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Publication Details

Journal
Cellular and Molecular Gastroenterology and Hepatology
Published
2025-10-21
DOI
https://doi.org/10.1016/j.jcmgh.2025.101665
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00
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An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease

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An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease

Clara Morral Martinez, Kai Tan, Christopher J. Lengner, Kathryn E. Hamilton, Chia‐Hui Chen, Judith R. Kelsen, Daniel Aleynick, MaryKate Fulton, Oliver Pickering, Zvi Cramer, Anusha Thadi, Sarah Weinbrom, Olivia T. Hix, Yusen Zhou, Meenakshi Bewtra, Tatiana A. Karakasheva, Jingya Qui, Yasin Uzun, Alyssa Laguerta, X Chen, Shaneice K. Nettleford, Máire Conrad, Andy J. Minn, Gloria E. Soto, Ning Li, Daana M. Roach, Ingrid Peterson, Rachael M. Edwards, Elizaveta Borodyanskaya, Erik B Hagen, Ian P. Yannuzzi, Zainab Haider
article en

Abstract

We have defined differences in the epithelial stem and progenitor compartment of patients with Crohn's disease that suggest aberrant stem cell differentiation and inflammatory gene expression arise and persist during disease.

Cellular and Molecular Gastroenterology and HepatologyVol. 20(3)
Children's Hospital of Philadelphia (US), Parker Institute for Cancer Immunotherapy (US), University of Pennsylvania (US), Penn State Milton S. Hershey Medical Center (US), Philadelphia University (US)
Openalex Percentile: Top 68%
Inflammatory Bowel Disease
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