An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease
We have defined differences in the epithelial stem and progenitor compartment of patients with Crohn's disease that suggest aberrant stem cell differentiation and inflammatory gene expression arise and persist during disease.
Authors
- Clara Morral Martinez (ORCID: https://orcid.org/0000-0003-0817-1595)
- Kai Tan (ORCID: https://orcid.org/0000-0002-9104-5567)
- Christopher J. Lengner (ORCID: https://orcid.org/0000-0002-0574-5189)
- Kathryn E. Hamilton (ORCID: https://orcid.org/0000-0001-9575-2499)
- Chia‐Hui Chen (ORCID: https://orcid.org/0000-0001-9927-6215)
- Judith R. Kelsen (ORCID: https://orcid.org/0000-0003-0038-318X)
- Daniel Aleynick
- MaryKate Fulton
- Oliver Pickering (ORCID: https://orcid.org/0009-0002-0860-2797)
- Zvi Cramer (ORCID: https://orcid.org/0000-0002-7386-3937)
- Anusha Thadi (ORCID: https://orcid.org/0000-0002-1271-0398)
- Sarah Weinbrom
- Olivia T. Hix (ORCID: https://orcid.org/0000-0001-8870-5571)
- Yusen Zhou (ORCID: https://orcid.org/0000-0002-9830-682X)
- Meenakshi Bewtra (ORCID: https://orcid.org/0000-0002-6489-7043)
- Tatiana A. Karakasheva (ORCID: https://orcid.org/0000-0001-9070-2804)
- Jingya Qui
- Yasin Uzun (ORCID: https://orcid.org/0000-0003-3478-3499)
- Alyssa Laguerta
- X Chen
- Shaneice K. Nettleford
- Máire Conrad (ORCID: https://orcid.org/0000-0003-3561-3029)
- Andy J. Minn (ORCID: https://orcid.org/0000-0003-1418-0906)
- Gloria E. Soto
- Ning Li
- Daana M. Roach
- Ingrid Peterson
- Rachael M. Edwards
- Elizaveta Borodyanskaya
- Erik B Hagen
- Ian P. Yannuzzi
- Zainab Haider
Institutions
- Children's Hospital of Philadelphia (US)
- Parker Institute for Cancer Immunotherapy (US)
- University of Pennsylvania (US)
- Penn State Milton S. Hershey Medical Center (US)
- Philadelphia University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101665
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00