A Dual-compartment Scaffolding Role for Receptor for Activate C Kinase 1 in Hepatic Glucagon Signaling and Gluconeogenesis
RACK1 functions as a dual-compartment scaffold, assembling GCGR-PKA at the plasma membrane and PKAcα-CREB in the nucleus, enabling precise glucagon signaling and gluconeogenesis while sparing insulin pathways, thereby ensuring compartmentalized regulation of hepatic glucose homeostasis.
Authors
- Songhai Chen (ORCID: https://orcid.org/0000-0001-7316-7125)
- Cancan Lyu (ORCID: https://orcid.org/0000-0003-2078-3471)
- Ling Yang (ORCID: https://orcid.org/0000-0002-5506-7021)
Institutions
- University of Iowa (US)
- Neuroscience Institute (IT)
- Center for Neurosciences (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101666
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00