Synthesis of Selenylated Pyridones via Bromide‐Catalyzed Direct C( <i> sp <sup>2</sup> </i> )─H Bond Selenylation of Pyridones With Diselenides
A straightforward and sustainable platform for the efficient assembly of selenylated pyridones with pyridones and diselenides enabled by a cheap and green bromide catalyst was successfully reported. This method was highlighted by its readily available starting materials, metal-free, stoichiometric oxidant-free, simple catalytic system, and wide functional group compatibility. The potential synthetic utility of this strategy was demonstrated by its scalable-up reaction and diverse transformations. The preliminary mechanistic experiments revealed that a radical pathway was possibly involved.
Authors
- Feng Zhao (ORCID: https://orcid.org/0000-0001-5810-744X)
- Jinhui Cai (ORCID: https://orcid.org/0000-0002-7624-5499)
- Depeng Yang (ORCID: https://orcid.org/0000-0001-8753-3106)
- Zi Yang (ORCID: https://orcid.org/0000-0002-8377-118X)
- Mingming Yu (ORCID: https://orcid.org/0000-0002-4081-7774)
- Wenting Zhang (ORCID: https://orcid.org/0000-0001-5447-2300)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6097-2763)
- Yutao Peng (ORCID: https://orcid.org/0000-0003-0701-4571)
- Zijing Xing (ORCID: https://orcid.org/0009-0003-3411-1737)
Institutions
- Zhejiang Sci-Tech University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1002/asia.70391
- Citations
- 2
- Primary Topic
- Organoselenium and organotellurium chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.61