Growth hormone therapy and chromosomal mosaicism in turner syndrome: 25 years of growth outcomes in Taiwan

Growth hormone treatment in TS is beneficial, but final adult height is complex. Karyotype, including mosaicism, isn't a primary driver of adult height; instead, factors such as bone age at treatment initiation, pre-treatment height, and mid-parental height are stronger predictors. This emphasizes the need for early diagnosis, individualized treatment plans focusing on clinical assessments, and appropriately timed hormonal interventions.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2025-10-21
DOI
https://doi.org/10.3389/fendo.2025.1640414
Primary Topic
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Type
article
Field-Weighted Citation Impact
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article

Growth hormone therapy and chromosomal mosaicism in turner syndrome: 25 years of growth outcomes in Taiwan

Ying-Hua Huang, Fu‐Sung Lo, Yu‐Ting Chang
Frontiers in Endocrinology
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
article

Growth hormone therapy and chromosomal mosaicism in turner syndrome: 25 years of growth outcomes in Taiwan

Ying-Hua Huang, Fu‐Sung Lo, Yu‐Ting Chang
article en

Abstract

Growth hormone treatment in TS is beneficial, but final adult height is complex. Karyotype, including mosaicism, isn't a primary driver of adult height; instead, factors such as bone age at treatment initiation, pre-treatment height, and mid-parental height are stronger predictors. This emphasizes the need for early diagnosis, individualized treatment plans focusing on clinical assessments, and appropriately timed hormonal interventions.

Frontiers in EndocrinologyVol. 16
Chang Gung University (TW), Taipei Medical University Hospital (TW), Kaohsiung Chang Gung Memorial Hospital (TW), Linkou Chang Gung Memorial Hospital (TW)
Openalex Percentile: Top 68%
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
DOIOpen Access PDFOpenAlex
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Growth hormone therapy and chromosomal mosaicism in turner syndrome: 25 years of growth outcomes in Taiwan — Ying-Hua Huang, Fu‐Sung Lo, et al. · Frontiers in Endocrinology (2025) | TGRS Research Map | TGRS