Transcriptomics and network pharmacology reveal the potential mechanism related to integrated stress response in the treatment of osteoporosis by Jiawei Shentong Zhuyu Decoction and verified by RT-qPCR
This study identified <i>COL4A6</i> and <i>NKX3-1</i> as key biomarkers, providing new insights into the mechanisms associated with ISR in the treatment of OP using JWSTZYD.
Authors
- Weina Han (ORCID: https://orcid.org/0000-0001-7703-2957)
- Pengbo Han
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-9141-2593)
- Zhu Liu
- Jie Zhao (ORCID: https://orcid.org/0000-0001-7254-761X)
- Hongli Zhang
- Fangqin Li
Institutions
- Xi'an Medical University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- The Eighth Hospital of Xi'an (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fendo.2025.1618296
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00