High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body
In high-cholesterol absorbers, poor elimination of cholesterol from the body as bile acids and neutral sterols may indicate an increased risk of atherosclerosis. It can be prevented by decreasing cholesterol absorption and increasing reverse cholesterol transport by dietary means combined with ezetimibe and statin treatment, when needed.
Authors
- Jyri Lommi (ORCID: https://orcid.org/0000-0002-8125-5499)
- Piia Simonen (ORCID: https://orcid.org/0000-0002-3394-6420)
- Helena Gylling
- Juha P. Sinisalo (ORCID: https://orcid.org/0000-0002-0169-5137)
- Ingmar Wester
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Raisio (Finland) (FI)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1111/joim.70031
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto