Subchondral insufficiency fracture of the knee: progress in the pathogenesis and treatment

Subchondral Insufficiency Fracture of the Knee (SIFK) is a disease with unclear pathogenesis and rapid progression, it is prone to developing end-stage osteoarthritis. Due to the lack of a definitive treatment strategy for SIFK in the clinic, knee replacement is often the preferred measure. However, in recent years, as the disease has become better understood, more and more effective treatments have been proposed, but there is a lack of summarization. Therefore, this article summarizes its pathogenesis and therapeutic advances.

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Publication Details

Journal
Frontiers in Surgery
Published
2025-10-21
DOI
https://doi.org/10.3389/fsurg.2025.1640316
Primary Topic
Bone and Joint Diseases
Type
article
Field-Weighted Citation Impact
0.00

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article

Subchondral insufficiency fracture of the knee: progress in the pathogenesis and treatment

Bangjian He, Ziyue Wang, Hang Pei, Jiale Yuan et al.
Frontiers in Surgery
Bone and Joint Diseases
article

Subchondral insufficiency fracture of the knee: progress in the pathogenesis and treatment

Bangjian He, Ziyue Wang, Hang Pei, Jiale Yuan, Yi Zhang, Chao Wang
article en

Abstract

Subchondral Insufficiency Fracture of the Knee (SIFK) is a disease with unclear pathogenesis and rapid progression, it is prone to developing end-stage osteoarthritis. Due to the lack of a definitive treatment strategy for SIFK in the clinic, knee replacement is often the preferred measure. However, in recent years, as the disease has become better understood, more and more effective treatments have been proposed, but there is a lack of summarization. Therefore, this article summarizes its pathogenesis and therapeutic advances.

Frontiers in SurgeryVol. 12
Zhejiang Chinese Medical University (CN), Ningbo No. 2 Hospital (CN), County Hospital (GB), Ningbo No.6 Hospital (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 61%
Bone and Joint Diseases
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Subchondral insufficiency fracture of the knee: progress in the pathogenesis and treatment — Bangjian He, Ziyue Wang, et al. · Frontiers in Surgery (2025) | TGRS Research Map | TGRS