Immunological characteristics and functions of macrophages in Mycobacterium leprae infection
Our findings suggested the notable significance of macrophage polarization in leprosy. M1 macrophages exhibited a relatively strong bactericidal effect against M. leprae, while M2 macrophages might have been somewhat associated with pathogen persistence.
Authors
- Haiqin Jiang (ORCID: https://orcid.org/0000-0002-4924-0465)
- Hongsheng Wang (ORCID: https://orcid.org/0000-0001-6487-6309)
- Weijun Liu
- Xiaodong Zhang (ORCID: https://orcid.org/0000-0001-8771-7175)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12865-025-00759-8
- Primary Topic
- Leprosy Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province