Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry
These findings offer novel insights into the molecular mechanisms underlying ACTH response variability in IESS and propose candidate plasma protein biomarkers for predicting ACTH treatment efficacy. This study, combining DIA-MS proteomics with targeted ELISA validation in plasma from individuals with IESS, provides evidence that the identified proteins warrant further investigation as candidate biomarkers to refine therapeutic strategies and monitor patient responses.
Authors
- Dezhi Cao (ORCID: https://orcid.org/0000-0002-7424-8063)
- Dongfang Zou (ORCID: https://orcid.org/0000-0001-6726-8704)
- Zhiqiang Luo (ORCID: https://orcid.org/0000-0003-1002-9416)
- Jianxiang Liao (ORCID: https://orcid.org/0000-0001-9769-3365)
- Yan Hu (ORCID: https://orcid.org/0000-0003-1908-4892)
- Li Chen (ORCID: https://orcid.org/0000-0001-7670-8062)
- Haohua Huang
- Xia Zhao (ORCID: https://orcid.org/0000-0001-8108-6528)
- Xufeng Luo
Institutions
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12014-025-09559-z
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanming Project of Medicine in Shenzhen