Multiple primary malignant neoplasms and long‑term survival: A case report

At present, morbidity rates in patients with multiple primary malignant neoplasms (MPMNs) are continually improving as tumor diagnosis and treatment technology progress. The present study aimed to describe the rare case of a patient with MPMNs. Following initial detection of the first primary malignant tumor, the patient underwent six surgical interventions. The medical history showed that the patient had been sequentially diagnosed with seven types of primary tumors over a period of 38 years. These included sigmoid colon cancer, thyroid cancer, ileocecal adenocarcinoma, left lung invasive adenocarcinoma, bilateral breast invasive cancer and right lung invasive adenocarcinoma. Although this clinical presentation of MPMN is exceptionally uncommon, timely detection and consistent medical interventions have led to an increased survival period for affected patients. Therefore, the present study aimed to describe the diagnostic and therapeutic strategies used for the current patient, and to offer novel insights for the clinical management of similar conditions.

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Publication Details

Journal
Oncology Letters
Published
2025-10-21
DOI
https://doi.org/10.3892/ol.2025.15351
Primary Topic
Multiple and Secondary Primary Cancers
Type
article
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article

Multiple primary malignant neoplasms and long‑term survival: A case report

Ke Huang, Shui-Bo Zhu, Biao Xie
Oncology Letters
Multiple and Secondary Primary Cancers
article

Multiple primary malignant neoplasms and long‑term survival: A case report

Ke Huang, Shui-Bo Zhu, Biao Xie
article en

Abstract

At present, morbidity rates in patients with multiple primary malignant neoplasms (MPMNs) are continually improving as tumor diagnosis and treatment technology progress. The present study aimed to describe the rare case of a patient with MPMNs. Following initial detection of the first primary malignant tumor, the patient underwent six surgical interventions. The medical history showed that the patient had been sequentially diagnosed with seven types of primary tumors over a period of 38 years. These included sigmoid colon cancer, thyroid cancer, ileocecal adenocarcinoma, left lung invasive adenocarcinoma, bilateral breast invasive cancer and right lung invasive adenocarcinoma. Although this clinical presentation of MPMN is exceptionally uncommon, timely detection and consistent medical interventions have led to an increased survival period for affected patients. Therefore, the present study aimed to describe the diagnostic and therapeutic strategies used for the current patient, and to offer novel insights for the clinical management of similar conditions.

Oncology LettersVol. 30(6)
Central Hospital of Wuhan (CN), Wuhan General Hospital of Guangzhou (CN)
Openalex Percentile: Top 60%
Multiple and Secondary Primary Cancers
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Multiple primary malignant neoplasms and long‑term survival: A case report — Ke Huang, Shui-Bo Zhu, et al. · Oncology Letters (2025) | TGRS Research Map | TGRS