Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence
In conclusion, our findings suggest that tumoral CD8 + and CD20 + ICs are pivotal determinants of NAC response in TNBC. The enrichment of CD20 + IC under high-TIL conditions underscores the potential role of B-T cell interactions in shaping immune-mediated chemotherapy responses. These insights provide a foundation for leveraging immune-based biomarkers to stratify patients with TNBC and optimize NAC outcomes.
Authors
- Jiwon Ko (ORCID: https://orcid.org/0000-0003-2034-6730)
- Sung Gwe Ahn (ORCID: https://orcid.org/0000-0002-8778-9686)
- Joon Jeong (ORCID: https://orcid.org/0000-0003-0397-0005)
- Yoon Jin (ORCID: https://orcid.org/0000-0002-5967-4064)
- In Ho Park (ORCID: https://orcid.org/0000-0003-2190-5469)
- Heounjeong Go (ORCID: https://orcid.org/0000-0003-0412-8709)
- Jee Hung Kim (ORCID: https://orcid.org/0000-0002-9044-8540)
- Soong June Bae (ORCID: https://orcid.org/0000-0002-0012-9694)
- Su‐Jin Shin (ORCID: https://orcid.org/0000-0001-9114-8438)
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Gangnam Severance Hospital (KR)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13058-025-02132-4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yonsei University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Yonsei University College of Medicine