Spatiotemporal transcriptomic characteristics of immune and metabolic dysregulation during mouse brain aging
This work presented a high-resolution spatiotemporal transcriptomic atlas of mouse brain aging, revealed regionally staggered immune activation, contrasted metabolic adaptations, and illustrated PRC2-mediated epigenetic remodeling during brain aging. These insights advanced our understanding of brain aging mechanisms and identified region-specific therapeutic targets for precision interventions in neurodegenerative diseases.
Authors
- Baofa Sun (ORCID: https://orcid.org/0000-0002-8221-1279)
- Jiacong Wei (ORCID: https://orcid.org/0000-0002-6672-7531)
- Yuheng Yang (ORCID: https://orcid.org/0000-0003-2613-7091)
- Xueying Li (ORCID: https://orcid.org/0000-0003-1307-9187)
- Yajuan Hao (ORCID: https://orcid.org/0000-0002-8666-6545)
- Man Qin (ORCID: https://orcid.org/0000-0001-5791-3319)
- Jin Wan (ORCID: https://orcid.org/0000-0002-7424-9250)
- Xianhua Jin
- Fengcongzhe Gong
Institutions
- Tongji University (CN)
- Nankai University (CN)
- Shanghai Cancer Institute (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07171-1
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Science and Technology Commission of Shanghai Municipality