Runx1 drives cardiac fibrosis and heart failure through epigenetic activation of myofibroblasts in pressure overload-induced cardiac remodeling
Runx1 plays a pivotal role in cardiac fibroblast activation and fibrosis, likely through epigenetic regulation of Postn expression, thereby driving heart failure progression. Targeting Runx1 may represent a promising therapeutic strategy for heart failure.
Authors
- Jian Hua Huang (ORCID: https://orcid.org/0000-0003-3282-8892)
- Jianbing Zhu (ORCID: https://orcid.org/0000-0001-8186-9549)
- Zeqi Zheng
- Xiaoping Peng (ORCID: https://orcid.org/0000-0002-0401-7331)
- Yujing Zhang (ORCID: https://orcid.org/0000-0001-8451-2035)
- Xiang Wang (ORCID: https://orcid.org/0000-0001-5538-4310)
- Qian Wang (ORCID: https://orcid.org/0000-0002-7368-3645)
- Mingzhe Wang (ORCID: https://orcid.org/0000-0001-9659-4189)
- Lingbo Xia
- Wei Zhou (ORCID: https://orcid.org/0000-0002-3224-7046)
- Jun An
- Liao Geping
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Hypertension Institute (US)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12872-025-05222-5
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Health Commission of Jiangxi Province