Building a bovine blood DNA methylation epimap related to disease phenotypes
Our results suggest a dual role for VMCs and CMCs: while the stability of conserved sites is potentially associated with essential functions in cell development and homeostasis, variable sites may be involved in dynamically regulating gene transcription in response to internal or external stimuli. These insights underscore the epigenome's role in immune regulation and adaptive resilience in cattle.
Authors
- Marc‐André Sirard (ORCID: https://orcid.org/0000-0001-8667-6682)
- J.C.S. Marques (ORCID: https://orcid.org/0000-0001-9690-2567)
- R.L.A. Cerri (ORCID: https://orcid.org/0000-0002-8169-8900)
- Hélène Martin (ORCID: https://orcid.org/0009-0005-1606-8434)
- Lotfi Bouzeraa (ORCID: https://orcid.org/0009-0001-4770-369X)
Institutions
- Defence Research and Development Canada (CA)
- University of British Columbia (CA)
- Intertek (Canada) (CA)
- Université Laval (CA)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12864-025-12112-9
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Genome Canada