Establishment of sex-specific liver transcriptomes and H3K9me3 profiles during sexual maturity: the impact of maternal obesity
Collectively, this study highlights inherent sex differences in liver gene expression, and suggests that H3K9me3 plays a role in establishing sex-specific liver function during sexual maturation. Moreover, MO disrupts these patterns, which are not fully corrected by 5 weeks of postnatal dietary normalization.
Authors
- Guanglong Jiang (ORCID: https://orcid.org/0000-0002-9233-052X)
- Ajay K. Yadav (ORCID: https://orcid.org/0009-0009-4603-0081)
- Kok Lim Kua (ORCID: https://orcid.org/0000-0002-6351-4506)
- Núria Morral (ORCID: https://orcid.org/0000-0002-8932-2887)
- Arianna Harris-Kawano (ORCID: https://orcid.org/0000-0002-5810-9274)
- Hongyu Gao (ORCID: https://orcid.org/0000-0002-7462-8883)
- Jia Ji
- Romil Saxena (ORCID: https://orcid.org/0000-0002-1872-0431)
Institutions
- Emory University (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13293-025-00767-8
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Vanderbilt University
- National Institutes of Health
- School of Medicine, Indiana University