Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer
This is the first study to generate mAbs for the HLA-G2/6 and HLA-G1/4/5 isoforms. Our findings reveal that HLA-G2/6-but not HLA-G1/4/5-expression is an independent prognostic indicator for patients with CRC. In the context of precision medicine, our study also suggests that HLA-G isoform typing may be necessary for HLA-G-targeted cancer immunotherapy.
Authors
- Aifen Lin (ORCID: https://orcid.org/0000-0001-6566-8368)
- Qiu-Yue Han (ORCID: https://orcid.org/0000-0002-2555-7580)
- Jiangang Zhang (ORCID: https://orcid.org/0000-0002-8523-6623)
- Wei‐Hua Yan (ORCID: https://orcid.org/0000-0003-1774-7699)
- Baohua Jia (ORCID: https://orcid.org/0000-0002-6703-477X)
- Xia Zhang (ORCID: https://orcid.org/0000-0002-9040-1486)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1672144
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Taizhou Municipal Science and Technology Bureau