Gut microbiota alterations and their association with tumorigenic pathways in colorectal cancer: insights from a pooled analysis of 109 microbiome datasets
Our study reveals a distinct gut microbiota signature in CRC and suggests functional interactions between microbial dysbiosis and host inflammatory responses. These findings emphasize the potential of microbiota-based interventions and microbial metabolites as adjunctive strategies for the management of CRC.
Authors
- Abdullah F. Aldairi (ORCID: https://orcid.org/0000-0003-2861-6299)
- Ahmad O. Babalghith (ORCID: https://orcid.org/0000-0001-6650-9158)
- Farkad Bantun (ORCID: https://orcid.org/0000-0002-7851-6977)
- Hani Faidah (ORCID: https://orcid.org/0000-0002-6671-313X)
- Mohammad A. Alobaidy (ORCID: https://orcid.org/0000-0002-6911-9179)
- Shafiul Haque (ORCID: https://orcid.org/0000-0002-2989-121X)
- Naif A. Jalal (ORCID: https://orcid.org/0000-0002-3866-1010)
- Faraz Ahmad (ORCID: https://orcid.org/0000-0003-4284-8045)
Institutions
- Umm al-Qura University (SA)
- Universidad Espíritu Santo (EC)
- Vellore Institute of Technology University (IN)
- Jazan University (SA)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13099-025-00712-5
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Jazan University