Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry

Overall, no changes were observed in the safety profile with long-term use of canakinumab in pediatric patients with SJIA. Particularly, no change in the frequency or severity of known ESIs occurred, and no new risks were identified. The findings suggest that canakinumab is effective in SJIA management and has a favorable safety profile with long-term use over a period of 5 years in real-world settings.

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Publication Details

Journal
Pediatric Rheumatology
Published
2025-10-21
DOI
https://doi.org/10.1186/s12969-025-01144-w
Primary Topic
Autoimmune and Inflammatory Disorders Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry

Leonard K. Kovalick, Homaira Rahimi, Dominic O. Co, Heather Van Mater et al.
Pediatric Rheumatology
Autoimmune and Inflammatory Disorders Research
article

Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry

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article en

Abstract

Overall, no changes were observed in the safety profile with long-term use of canakinumab in pediatric patients with SJIA. Particularly, no change in the frequency or severity of known ESIs occurred, and no new risks were identified. The findings suggest that canakinumab is effective in SJIA management and has a favorable safety profile with long-term use over a period of 5 years in real-world settings.

Pediatric RheumatologyVol. 23(1)
Novartis (Switzerland) (CH), University of Minnesota (US), Duke University (US), Clinical Research Institute (US), Novartis (India) (IN), Childhood Arthritis and Rheumatol­ogy Research Alliance (US), Novartis (United States) (US), Center for Discovery (US)
National Institutes of Health, School of Medicine, Duke University, Novartis Pharma, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Duke Clinical Research Institute
Openalex Percentile: Top 62%
Autoimmune and Inflammatory Disorders Research
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