DNA methylation profiles and cancer in children conceived after assisted reproductive technology
This study indicates that relatively few genes that are known targets for somatic/germline mutation in cancer experience DNA methylation changes in individuals conceived through ART. By contrast, DNA methylation disturbances reported in leukemia represent more than one-third of those associated with ART conception, thus raising the question of their role in leukemia risk in ART-conceived individuals. Among them, a few critical genes such as TP73, a tumor suppressor, were shown to be targeted for hypermethylation, both in ART and leukemia, warranting further investigation.
Authors
- Bastien Ducreux (ORCID: https://orcid.org/0000-0001-8636-7361)
- Catherine Patrat (ORCID: https://orcid.org/0000-0003-4885-8885)
- Patricia Fauque (ORCID: https://orcid.org/0000-0002-9708-1710)
- Akram Ghantous (ORCID: https://orcid.org/0000-0002-2582-6402)
- Lucile Ferreux (ORCID: https://orcid.org/0000-0002-4822-9176)
- Julie Firmin (ORCID: https://orcid.org/0000-0001-8269-7515)
- Jacqueline Clavel (ORCID: https://orcid.org/0000-0002-3616-7676)
- Zdenko Herceg (ORCID: https://orcid.org/0000-0003-4109-3154)
- Mary Callanan (ORCID: https://orcid.org/0000-0002-9088-0720)
Institutions
- Inserm (FR)
- Université de Bourgogne (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- CHU Dijon Bourgogne (FR)
- Institut Cochin (FR)
- Centre international de recherche sur le cancer (FR)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13148-025-01982-1
- Primary Topic
- Assisted Reproductive Technology and Twin Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00