Carnosic acid alleviated periodontitis by inhibiting ferroptosis via the Nrf2/GPX4 pathway
The current research is the first to elucidate that CA can alleviate periodontitis pathological damage by suppressing ferroptosis via activating the Nrf2/GPX4 signaling axis. This enriches the pharmacological action spectrum of CA and provides new targets and a theoretical basis for periodontitis intervention strategies based on ferroptosis regulation.
Authors
- Yushen Li (ORCID: https://orcid.org/0009-0000-2843-1265)
- Xiantao Chen (ORCID: https://orcid.org/0000-0002-2889-9519)
- Qi Zhao (ORCID: https://orcid.org/0000-0002-5969-6407)
- Zhihui Liu (ORCID: https://orcid.org/0000-0001-8650-9104)
- Rui Wang (ORCID: https://orcid.org/0000-0003-3454-7082)
- Bowei Wang (ORCID: https://orcid.org/0000-0002-9400-0698)
- Yifei Dai (ORCID: https://orcid.org/0000-0001-8791-8532)
- Jiahui Yu
- Jiatong Zou
- Jiajun Xin
Institutions
- Jilin University (CN)
- Jilin Jianzhu University (CN)
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12903-025-07048-1
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- Jilin University