Phenotype switching in highly invasive resistant to vemurafenib and cobimetinib melanoma cells
In summary, our study characterized a significantly more invasive phenotype of double-resistant cell lines compared to melanoma cells sensitive to BRAF and MEK inhibitors. Successful inhibition of this phenotype could result in more effective therapy and thus a better prognosis for patients.
Authors
- Dorota Nowak (ORCID: https://orcid.org/0000-0002-6426-1686)
- Rafał Matkowski (ORCID: https://orcid.org/0000-0002-1705-5097)
- Magdalena Kot (ORCID: https://orcid.org/0000-0001-8374-2090)
- Aleksandra Simiczyjew (ORCID: https://orcid.org/0000-0002-6060-2375)
- Marcin Ziętek (ORCID: https://orcid.org/0000-0002-7890-3483)
- Michał Majkowski (ORCID: https://orcid.org/0000-0002-9118-0005)
Institutions
- University of Wrocław (PL)
- Wroclaw Medical University (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12964-025-02452-0
- Citations
- 4
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Narodowym Centrum Nauki