MiR-877, an exosomal miRNA from mechanical stretch induced adipose derived stromal cells, enhances fracture healing in nonunion rats with type 2 diabetes mellitus
This study reveals a novel mechanobiological mechanism whereby mechanical stretch modulates exosomal miRNA content to potentiate fracture repair. Transplantation of LMS-ADSC-Exos accelerates bone regeneration via miR-877-mediated osteogenic and angiogenic pathways. These findings highlight the therapeutic potential of mechanically stimulated ADSC-derived exosomes as natural bioactive nanotherapeutics for diabetic fracture nonunion.
Authors
- Liang Tian
- Aixi Yu (ORCID: https://orcid.org/0000-0002-5723-6140)
- Chao Jian (ORCID: https://orcid.org/0000-0002-3624-5558)
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-1176-7659)
- Changjiang Liu (ORCID: https://orcid.org/0000-0002-5654-3886)
- Junwei Su (ORCID: https://orcid.org/0009-0005-7098-6498)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13287-025-04692-w
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University