NR2F6 regulates Temozolomide resistance in glioma via the E2F2-PARP1 pathway
In brief, NR2F6, as a nuclear transcription factor, enhances the transcription of E2F2.The increased expression of E2F2 enhances PARP1 expression, which in turn facilitates TMZ-mediated DNA damage repair, thereby diminishing glioma sensitivity to TMZ.
Authors
- Cuncun Yang
- Zhaohao Wang (ORCID: https://orcid.org/0009-0006-0670-5708)
- Rongrong Li (ORCID: https://orcid.org/0000-0003-0019-7248)
- Lili Yi
- Pengfei Xue (ORCID: https://orcid.org/0009-0007-2991-4972)
- Lili Yan (ORCID: https://orcid.org/0000-0002-6261-2542)
- Yaxin Liang
- Conghui Tian (ORCID: https://orcid.org/0000-0001-9546-9327)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0003-0041-0758)
- Xin Li (ORCID: https://orcid.org/0000-0001-8328-4894)
- Bo Wang (ORCID: https://orcid.org/0000-0002-6047-1221)
- Juan Zheng (ORCID: https://orcid.org/0000-0001-8240-0638)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Shandong Tumor Hospital (CN)
- Yantaishan Hospital (CN)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12935-025-03986-6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00