Determining the minimum inhibitory concentrations of pyrazinamide against Mycobacterium tuberculosis clinical isolates at a neutral pH of 6.8 using the broth microdilution method
This approach overcomes the limitations of existing acidic pH-based PZA susceptibility tests and provides a reliable, accurate, cost-effective method for detecting improved PZA resistance. Implementing this method could significantly enhance TB treatment, resistance surveillance, and efforts to combat drug-resistant TB.
Authors
- Jessica L. Reynolds (ORCID: https://orcid.org/0000-0001-5188-6786)
- Maria Tamblin
- Liang Chen (ORCID: https://orcid.org/0000-0002-3787-8832)
- Wanliang Shi
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1688772
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Small Business Innovation Research
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases