Integrating single-cell RNA sequencing and spatial multi-omics reveals the molecular signature of regeneration after spinal cord injury
In this study, we have identified three distinct cell subsets that express markers associated with wound healing and may promote regenerative processes, and we have determined their spatial transcriptional and metabolic features enriched within these regions. Our dataset represents a valuable resource that offers novel mechanistic insights into the pathobiology of spinal cord injury.
Authors
- Haoru Dong
- Haiyue Lin
- Rong Xie (ORCID: https://orcid.org/0000-0002-8277-7280)
- Zezhen Zhang
- Xiaomu Li (ORCID: https://orcid.org/0000-0001-8337-0207)
- Jian‐Lan Zhao (ORCID: https://orcid.org/0000-0001-6178-2470)
- Yufeng Tao
- Shiyi Cai
- Yuanqing Ding
- Xingyu Chen (ORCID: https://orcid.org/0000-0002-9284-4950)
- Xiao Xiao (ORCID: https://orcid.org/0000-0003-3608-6208)
- Longnian Zhou
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhongshan Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s40364-025-00845-4
- Citations
- 1
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Fudan University