Metabolic alterations in erythrocytes associated with long-term hypoxia at high altitude
In conclusion, metabolomics and validation measurements reveal a distinct remodeling of the antioxidant defense system in erythrocytes under long-term hypoxia and suggest a pronounced influence of environmental factors on erythrocyte metabolism, offering new insights into hypoxic adaptations.
Authors
- Yangzhou Jiang (ORCID: https://orcid.org/0000-0001-5007-5826)
- Lanyue Hu (ORCID: https://orcid.org/0000-0003-1921-3340)
- Yanni Xiao
- Chengning Tan
- Qian Ran
- Peipei Xue
- Xiaojie Wang (ORCID: https://orcid.org/0000-0001-9968-0373)
- Li Chen (ORCID: https://orcid.org/0000-0003-4464-6383)
- Xiaoliang Li (ORCID: https://orcid.org/0000-0001-5448-7318)
- Zhongjun Li (ORCID: https://orcid.org/0000-0003-2260-7682)
- Chao Zhou (ORCID: https://orcid.org/0000-0001-9099-9185)
- Teng Yu (ORCID: https://orcid.org/0000-0001-7069-4480)
- Li‐xin Xiang (ORCID: https://orcid.org/0000-0002-7136-7729)
- Maoshan Chen (ORCID: https://orcid.org/0000-0002-3827-4969)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Army Medical University (CN)
- Dalian Medical University (CN)
- Ministry of Education (SA)
- Shiga University of Medical Science Hospital (JP)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Xinqiao Hospital (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chongqing Three Gorges University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12864-025-12107-6
- Citations
- 1
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Chongqing Municipal Education Commission
- Army Medical University
- National Key Research and Development Program of China