Strain-level characterization of bacterial pathogens using metagenomic sequencing for patients with pneumonia
The heterogeneity in virulence and antimicrobial resistance among CCs, together with the prevalence of strain-level co-infections, highlights the need to extend pathogen identification to the strain level. Under current technical conditions, mNGS is a more suitable subtyping tool compared to culture and mTGS.
Authors
- Yake Yao
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Hua Zhou (ORCID: https://orcid.org/0000-0001-6397-3203)
- Chao Liu (ORCID: https://orcid.org/0000-0001-9821-3570)
- Xi Li (ORCID: https://orcid.org/0000-0001-7106-1677)
- Yan Yao (ORCID: https://orcid.org/0009-0002-0700-7654)
- Ye Feng (ORCID: https://orcid.org/0000-0002-6551-1560)
- Qiuli Chen (ORCID: https://orcid.org/0000-0002-9550-7327)
- Dan Zhu (ORCID: https://orcid.org/0009-0006-8630-193X)
- Ying Mao (ORCID: https://orcid.org/0000-0001-8055-115X)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou DAC Biotech (China) (CN)
- Dian Diagnostics (China) (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Jinhua Central Hospital (CN)
- Hangzhou Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07134-6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China