Use of an extrasaccular flow diverter, eCLIPs eBFD, to treat a wide-neck bifurcation aneurysm (WNBA) in a patient requiring long-term anticoagulation

Wide neck bifurcation aneurysms are treated by intrasaccular implants, stent-assisted coiling, or flow diverters (FDs). The latter two options require long-term dual anti-platelet agents (DAPTs) and the former require access to the vulnerable aneurysm dome.<sup>1- 5</sup> In patients requiring oral anticoagulation (OAC), an alternative treatment strategy would be advantageous to mitigate the foregoing risks. This report describes using a dedicated bifurcation FD, eCLIPs eBFD, to treat a basilar tip bifurcation aneurysm in a patient with atrial fibrillation requiring long-term OACs. The non-tubular eBFD aneurysm neck-bridging implant provides coil-retaining and flow diverting features and serves as a platform for endothelial growth.<sup>6, 7</sup> It has shown flow velocity reduction at a bifurcation equivalent to a tubular FD at a sidewall.<sup>8</sup> In this case, eBFD, without coils, resulted in protracted intrasaccular stasis and resulted in complete aneurysm occlusion and neck remodeling within three months of discontinuation of dual anti-platelet therapy, without interrupting OAC.

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Publication Details

Journal
Interventional Neuroradiology
Published
2025-10-21
DOI
https://doi.org/10.1177/15910199251389061
Primary Topic
Intracranial Aneurysms: Treatment and Complications
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article
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article

Use of an extrasaccular flow diverter, eCLIPs eBFD, to treat a wide-neck bifurcation aneurysm (WNBA) in a patient requiring long-term anticoagulation

Ronni Mikkelsen, Leif Hovgaard Sørensen
Interventional Neuroradiology
Intracranial Aneurysms: Treatment and Complications
article

Use of an extrasaccular flow diverter, eCLIPs eBFD, to treat a wide-neck bifurcation aneurysm (WNBA) in a patient requiring long-term anticoagulation

Ronni Mikkelsen, Leif Hovgaard Sørensen
article en

Abstract

Wide neck bifurcation aneurysms are treated by intrasaccular implants, stent-assisted coiling, or flow diverters (FDs). The latter two options require long-term dual anti-platelet agents (DAPTs) and the former require access to the vulnerable aneurysm dome.<sup>1- 5</sup> In patients requiring oral anticoagulation (OAC), an alternative treatment strategy would be advantageous to mitigate the foregoing risks. This report describes using a dedicated bifurcation FD, eCLIPs eBFD, to treat a basilar tip bifurcation aneurysm in a patient with atrial fibrillation requiring long-term OACs. The non-tubular eBFD aneurysm neck-bridging implant provides coil-retaining and flow diverting features and serves as a platform for endothelial growth.<sup>6, 7</sup> It has shown flow velocity reduction at a bifurcation equivalent to a tubular FD at a sidewall.<sup>8</sup> In this case, eBFD, without coils, resulted in protracted intrasaccular stasis and resulted in complete aneurysm occlusion and neck remodeling within three months of discontinuation of dual anti-platelet therapy, without interrupting OAC.

Interventional Neuroradiology
Aarhus University Hospital (DK)
Openalex Percentile: Top 57%
Intracranial Aneurysms: Treatment and Complications
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Use of an extrasaccular flow diverter, eCLIPs eBFD, to treat a wide-neck bifurcation aneurysm (WNBA) in a patient requiring long-term anticoagulation — Ronni Mikkelsen, Leif Hovgaard Sørensen · Interventional Neuroradiology (2025) | TGRS Research Map | TGRS