Controllable synthesis of N–H or <i>N</i> -Me C7-substituted indazoles <i>via</i> a cascade reaction of α-diazo esters with aryne precursors
A [3 + 2] cycloaddition reaction utilizing cyclic diaryl λ 3 -bromanes and α-diazo esters to deliver either N–H or N -Me indazoles in a controllable manner is reported. DFT calculations explain the regioselectivity and the mechanism.
Authors
- S. M. Jia (ORCID: https://orcid.org/0000-0002-5203-8321)
- Wan‐Xuan Zhang
- Liang‐Qiu Lu (ORCID: https://orcid.org/0000-0003-2177-4729)
- Bin‐Jie Li (ORCID: https://orcid.org/0009-0001-5528-9839)
- Qiang Wang (ORCID: https://orcid.org/0000-0001-5095-4062)
- Yuxuan Zhang (ORCID: https://orcid.org/0000-0001-6205-7684)
- Jing‐Yi Fan
- Linxing Zhang (ORCID: https://orcid.org/0000-0002-2717-8410)
- Ming-Chuan Wang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Central China Normal University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1039/d5qo01181g
- Citations
- 1
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94