Managing treatment-resistant schizophrenia following clozapine cessation: a case report of xanomeline–trospium and olanzapine combination therapy

Clozapine-related VTE/PE represents a serious clinical dilemma. This case illustrates the potential of muscarinic-dopaminergic strategies to restore stability in TRS when clozapine is no longer an option.

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Publication Details

Journal
Frontiers in Psychiatry
Published
2025-10-21
DOI
https://doi.org/10.3389/fpsyt.2025.1679678
Citations
2
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
2.94
Controls
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article

Managing treatment-resistant schizophrenia following clozapine cessation: a case report of xanomeline–trospium and olanzapine combination therapy

Xiao Xiong You, Jason Hershberger, J Alonso, Nils S. Went et al.
2 citations
Frontiers in Psychiatry
Schizophrenia research and treatment
2.94
article

Managing treatment-resistant schizophrenia following clozapine cessation: a case report of xanomeline–trospium and olanzapine combination therapy

Xiao Xiong You, Jason Hershberger, J Alonso, Nils S. Went, Rosemarie R. Rigunay
article en
2 citations

Abstract

Clozapine-related VTE/PE represents a serious clinical dilemma. This case illustrates the potential of muscarinic-dopaminergic strategies to restore stability in TRS when clozapine is no longer an option.

Frontiers in PsychiatryVol. 16
Brookdale University Hospital and Medical Center (US)
Openalex Percentile: Top 8%
Schizophrenia research and treatment
2.94
DOIOpen Access PDFOpenAlex
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Managing treatment-resistant schizophrenia following clozapine cessation: a case report of xanomeline–trospium and olanzapine combination therapy — Xiao Xiong You, Jason Hershberger, et al. · Frontiers in Psychiatry (2025) | TGRS Research Map | TGRS