Regulation of macrophages in the dorsal root ganglion through TGF-β1 inhibits painful traumatic neuroma
These findings suggest that TGF-β reduces the M1/M2 macrophage ratio by mediating the polarization direction of macrophages within DRGs. This mechanism may block the transmission of peripheral nociceptive signals, thereby promoting the repair of nerve injury. The study provides concrete evidence to guide the development of new therapeutic strategies for painful neuroma.
Authors
- Chuanpeng Xia
- Hede Yan (ORCID: https://orcid.org/0000-0003-1276-3059)
- Ke Wang (ORCID: https://orcid.org/0000-0001-6776-4935)
- Mazhar Ali Raza
- Jinghao Liang
- Long Wu (ORCID: https://orcid.org/0009-0009-1531-396X)
- Yu Chen (ORCID: https://orcid.org/0000-0001-5139-9750)
- Anhao Guo
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Wenzhou Municipal Sci-Tech Bureau (CN)
- Zhejiang Provincial People's Hospital (CN)
- Zhejiang Mariculture Research Institute (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07143-5
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province