Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank
Together, these results provide evidence of selection events consistent with historical coronavirus epidemic(s) originating in East Asia. These results show how biobank-scale datasets and evolutionary genomics theory can provide insight into the study of past epidemics. The results also highlight how historic infectious disease epidemics can shape the genetic architecture of present-day human populations.
Authors
- George Davey Smith (ORCID: https://orcid.org/0000-0002-1407-8314)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Sam Morris (ORCID: https://orcid.org/0000-0003-4067-1100)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Liming Li (ORCID: https://orcid.org/0000-0001-5873-7089)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Kuang Lin (ORCID: https://orcid.org/0000-0003-3017-6026)
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Peking University (CN)
- University of Bristol (GB)
- University of Oxford (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12864-025-11876-4
- Primary Topic
- Evolution and Genetic Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00