FTO enhances OSCC progression via m⁶A-dependent stabilization of PKM2 mRNA through YTHDF2 modulation
These findings define an FTO/m⁶A/YTHDF2/PKM2 axis that promotes OSCC progression through glycolytic reprogramming and tumor growth, highlighting a potential metabolic vulnerability for therapeutic intervention.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8693-3060)
- Wensheng Ma (ORCID: https://orcid.org/0000-0003-3288-1239)
- Lina Liu (ORCID: https://orcid.org/0000-0002-6006-0027)
- Jie Wu (ORCID: https://orcid.org/0000-0001-5143-9425)
- Ru Wang (ORCID: https://orcid.org/0000-0003-1064-9615)
- Jiayin Deng (ORCID: https://orcid.org/0000-0001-7381-4927)
Institutions
- Tianjin University (CN)
- Tissue Regeneration Systems (United States) (US)
- Tianjin Stomatological Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Head & Face Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13005-025-00547-0
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61