Effect of monkeypox virus B14R protein fragments binding to IL-1β on apoptosis in HeLa cells
These results reveal distinct anti-apoptotic profiles of B14R isoforms and suggest that B14R-180 may enhance MPV immune evasion through high-affinity IL-1β binding. These findings provide critical mechanistic insights to guide the development of MPV vaccines and targeted therapeutic strategies.
Authors
- Yiyue Ge (ORCID: https://orcid.org/0000-0002-4839-5334)
- Yuhan Ding (ORCID: https://orcid.org/0009-0006-5253-9915)
- Shuo Ning (ORCID: https://orcid.org/0000-0002-9859-258X)
- Heng Rong
- Fengjuan Shi (ORCID: https://orcid.org/0009-0005-4601-6539)
- Lunbiao Cui (ORCID: https://orcid.org/0000-0001-6212-6053)
- Jinlei Guo (ORCID: https://orcid.org/0000-0002-4594-9696)
- Qiao Qiao (ORCID: https://orcid.org/0000-0002-6841-3771)
- Xiaojuan Zhu (ORCID: https://orcid.org/0000-0002-3782-1342)
- Tao Wu (ORCID: https://orcid.org/0000-0002-8786-536X)
- Kangchen Zhao
- Yunfeng Shan
Institutions
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12985-025-02962-w
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province