Mesenchymal stromal cells modulate neutrophil phenotype via paracrine signals
Our findings indicate that MSCs can modulate neutrophil responses, underscoring the nuanced effects of MSC-based approaches in ischemic heart disease. These results suggest that anti-inflammatory effects observed under controlled conditions may not fully translate in vivo, highlighting the importance of context when evaluating MSC-based therapies.
Authors
- Mihai Bogdan Preda (ORCID: https://orcid.org/0000-0003-2500-4078)
- Laura Cherry
- Sinziana Popescu
- Letiția Ciortan
- Bogdan Cosman
- Maya Simionescu (ORCID: https://orcid.org/0000-0003-2077-0400)
- Alexandrina Burlacu (ORCID: https://orcid.org/0000-0001-8811-2098)
- Fabio Martelli (ORCID: https://orcid.org/0000-0002-8624-7738)
- Carmen Alexandra Neculachi (ORCID: https://orcid.org/0000-0002-2188-4699)
- Elena Butoi (ORCID: https://orcid.org/0000-0001-5748-5641)
- Evelyn-Gabriela Nastase-Rusu
- Catalina Iolanda Marinescu-Colan
Institutions
- IRCCS Policlinico San Donato (IT)
- Romanian Academy (RO)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13287-025-04684-w
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitatea de Medicină şi Farmacie "Carol Davila" Bucureşti