Megasphaera contributes to lactate-driven valerate production in the human gut
This study brings forward new mechanistic understanding on the intestinal microbial formation of the SCCA valerate. Our findings identified Megasphaera as an infrequently occurring and low abundant keystone taxon contributing to lactose/lactate-driven valerate production in overweight/obese women. Our results highlight that the presence of Megasphaera affects the fermentative response to daily consumption of fermented dairy. Video Abstract.
Authors
- Line Barner Dalgaard (ORCID: https://orcid.org/0000-0001-7676-5323)
- Jan Hošek (ORCID: https://orcid.org/0000-0003-0975-1671)
- Clarissa Schwab (ORCID: https://orcid.org/0000-0002-5443-1602)
- Menşure Elvan (ORCID: https://orcid.org/0000-0003-2820-1122)
- Line Thams (ORCID: https://orcid.org/0000-0003-4395-1394)
- Mette Hansen (ORCID: https://orcid.org/0000-0002-9383-8202)
- Angeliki Marietou (ORCID: https://orcid.org/0000-0003-4756-0067)
- Lucia Huertas‐Díaz (ORCID: https://orcid.org/0000-0001-8273-841X)
Institutions
- Aarhus University (DK)
Publication Details
- Journal
- Microbiome
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s40168-025-02207-6
- Citations
- 3
- Primary Topic
- Therapeutic Uses of Natural Elements
- Type
- article
- Field-Weighted Citation Impact
- 6.41
Funders
- Aarhus Universitet