FL496, an FL118-derived small molecule, induces growth inhibition, senescence, and apoptosis of malignant pleural mesothelioma (MPM) cells, and exhibits anti-MPM tumor efficacy strikingly superior to the pemetrexed-cisplatin combination
Together, these results indicate that FL496 is a promising anti-MPM small molecule, and its high anti-MPM potential is worthy of being further explored as a monotherapeutic agent to treat MPM patients in clinical trials.
Authors
- Emma Zhang (ORCID: https://orcid.org/0000-0002-7504-6148)
- Ieman Aljahdali
- Fengzhi Li (ORCID: https://orcid.org/0000-0002-2299-7951)
- Xiang Ling
- Aimee Stablewski (ORCID: https://orcid.org/0000-0001-9774-429X)
- Wenjie Wu (ORCID: https://orcid.org/0000-0002-0907-0561)
- Dan Li (ORCID: https://orcid.org/0000-0002-5450-9975)
- Wenchao Wang (ORCID: https://orcid.org/0000-0003-0757-4878)
- Qingyong Li (ORCID: https://orcid.org/0000-0003-1492-3909)
- Renyuan Zhang (ORCID: https://orcid.org/0000-0003-1435-5075)
- Rami G. Azrak
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Taif University (SA)
- Canget BioTekpharma (United States) (US)
- Cancer Genetics (United States) (US)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13046-025-03547-9
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mesothelioma Applied Research Foundation
- Pancreatic Cancer Action Network
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Institutes of Health
- National Key Research and Development Program of China
- National Cancer Institute
- Natural Science Foundation of Zhejiang Province