The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts
GPX4 was positively regulated by YAP1, which in turn inhibited ferroptosis and enhanced osteogenic potential of osteoblasts, thereby alleviating OA progression.
Authors
- Mingsi Deng
- Zhenning Wang (ORCID: https://orcid.org/0000-0003-0557-3097)
- Liangjian Chen (ORCID: https://orcid.org/0000-0001-7038-9144)
- Lanlin Hu (ORCID: https://orcid.org/0009-0007-2026-5566)
- Gengyan Liu (ORCID: https://orcid.org/0000-0001-9300-5617)
- Jia Luo (ORCID: https://orcid.org/0000-0003-4936-7586)
- Zhipeng Tang (ORCID: https://orcid.org/0000-0002-6625-6813)
- Yong Zhou (ORCID: https://orcid.org/0000-0003-3309-2565)
- Ruimin Tang
Institutions
- Central South University (CN)
- Changsha University (CN)
- Jining Traditional Chinese Medicine Hospital (CN)
- Hegang People's Hospital (CN)
- Stomatology Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s10020-025-01374-4
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52