A novel synbiotic formulation prevents calcium oxalate stones by restoring gut microbiota homeostasis
Our findings demonstrate that synbiotic intervention effectively reverses EG-induced hyperoxaluria by reversing gut microbiota dysbiosis to modulate oxalate homeostasis. Thus, this study not only proposes a synbiotic formulation for nephrolithiasis prevention but also elucidates its mechanistic basis, offering potential therapeutic advancements in disease management.
Authors
- Wenlong Wan
- Junlin Lu (ORCID: https://orcid.org/0000-0002-3438-0297)
- Yang Xun (ORCID: https://orcid.org/0000-0002-4244-9805)
- Xianmiao Li (ORCID: https://orcid.org/0000-0001-7189-1136)
- Yirixiatijiang Amier
- Yuanyuan Yang (ORCID: https://orcid.org/0000-0001-8606-079X)
- Yongqi Wang (ORCID: https://orcid.org/0000-0003-2894-5471)
- J. Madhusudana Rao
- Xiao Yu (ORCID: https://orcid.org/0000-0002-9614-7239)
- Guo-Rui-Yu Lyu
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12866-025-04408-3
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China